10^th International Conference on Brain Injury & Neuroscience August 17-18, 2020 Copenhagen, Denmark

Biography:

Kelly Thune, B.S. Biology, M.A.T Science Education., C.A.S. Education Leadership, Syracuse University brings expertise in the area of school leadership, developing collaborative cultures for change, STEAM/STEM initiatives, designing optimal learning environments, personal and professional transformation, and yoga for brain injury. In her role as a school leader, she was credited 2013 ESSAA NYS Zone 5 Administrator of the Year, 2013 NYSSBA Be The Change for Kids Innovation Award, 2013 PEB STEM Program of the Year Award and 2010 NYS ASCD Educating the Whole Child for the 21st Century Award. In 2017, she suffered a second and significant brain injury that was the impetus of learning and advocating for brain injury. She is an advocate and presenter for the New York State Brain Injury Association. She has written a book Sisu To A New You that is currently in the edit phase of publishing. sisutoanewyou.co

Abstract:

Sisu (both noun and verb) is a Finnish word that loosely translates to having perseverance, integrity, and tenacity when faced with life’s most significant challenges with an emphasis on short term emphasis, action mindset, and a concept that is emerging in the field of positive psychology. Literature in concussion/mTBI therapy including John Leddy’s April 2019 study regarding concussion and submaximal exercise crossed with the Emilia Lahti’s research on sisu provides the basis of this unique cultural-based self help plan. The polarity of pre-brain injury capacity and post-brain injury capacity provides a basis for change.The inspiring elements of this plan are: Sisu requires confronting your challenges. Sisu is finding enjoyment in discomfort.  Sisu demonstrates exercise/training is medicine. Sisu involves the role of reflection. Sisu is learning and reason informed. Sisu is making connections and strengthening relationships (including asking for help.)Sisu is finding balance and purpose, visioning, and doing.

Biography:

Dr. Roderick Sembrano has completed his Medical Degree from the University of the Philippines, College of Medicine, in Manila, Philippines. He completed his residency training in Physical Medicine & Rehabilitation (PM&R) at East Carolina University, Pitt County Memorial Hospital, in Greenville, North Carolina USA. Currently, he serves at the Medical Director of the Brain Injury Program at Northeast Rehabilitation Hospital Network in Salem, New Hampshire USA.

Abstract:

CASE DESCRIPTION: The patient became unresponsive and suffered a pulseless electrical activity with cardiorespiratory arrest related to overdose of fentanyl and cocaine in the community with successful cardiopulmonary resuscitation and return of spontaneous circulation.  On arrival to the emergency department patient underwent extensive work-up including imaging studies without any spinal fractures or intracranial pathology with CT scans. Stimulus-induced myoclonus was noted a few weeks during the hospitalization.  Patient had a brain MRI as part of the work-up and at that time did not show any evidence of anoxia.  Neurology diagnosed the patient with LAS and treated with valproic acid, levetiracetam and intermittent use of benzodiazepines with note of relative improvement of myoclonus.

Biography:

Hashim Talib Hashim is a fourth year medical student in Baghdad medical college. He is a researcher and he presented many researches in medicine in many conferences and published in many journals. He is the owner of the postconsciousness theory and the owner of Genes' communication 

Abstract:

The three levels of awareness in human consciousness which are divided by Freud: the conscious, preconscious, and unconscious. Each of them interferes with Freud’s ideas of the id, ego, and superego.Our Study which is cross sectional study conducted as an interview survey for one month, involved 167 participants from 21 countries. We used self - structured questionnaire which was tested for validity and ReliabilityAll the participants were well informed about the purpose of our study and what we are testing for before we gained their consent.We found that 62% feel that they need to do this work and they will not do it again, but 38% do not feel that, while 59.9% follow their feelings to do the wrong thing and convince themselves not to do it again but 40.1% do not.There is a significant difference between people who feel guilty on a work and the people who feel that they need to do the wrong thing and they will never do it again.There is a significant difference too between people who feel that they need to do the wrong thing because they need it and the people who follow that feeling.The feeling of the need to do any work and it will not occur again is not under the control of the three levels of consciousness described by Sigmoid Freud, so the need to develop a new level of consciousness which we called it (Postconsciousness) is necessary to explain these feelings in psychology.

Biography:

Prof. Dr. Anil Batta is presently professor & Head with senior consultant in Govt. Medical College, Amritsar. He did his M.B.B.S. and M.D. in Medical Biochemistry from Govt. Medical College, Patiala in 1984 and 1991, respectively. His research interest is mainly in clinical application especially cancer and drug de-addiction. He has supervised more than 25 M.D., M.Sc. and Doctorate researches and published more than 130 international research papers. He is the chief editor of America’s Journal of Biochemistry. He is also working as advisor to the editorial board of International Journal of Biological and Medical Research. He has been deputed member Editorial Board of numerous International & National Medical Journals of Biochemistry. He has also been attached as technical advisor to various national and international conferences in Biochemistry. He has been attached as hi-tech endocrinal, genetics and automated labs of Baba Farid Univ. of Health Sciences, Faridkot. He has chaired various sessions in the Biochemistry meets. He has been designated as member Editorial Board of various in US and other European Courtiers. He is also involved in various research projects at Govt. Medical, Amritsar. He has done superspecialisation in Drug-de-addiction from PGIMER, Chandigarh.

Abstract:

Traumatic brain injury (TBI) is a worldwide public health problem typically caused by contact and inertial forces acting on the brain. Recent attention has also focused on the mechanisms of injury associated with exposure to blast events or explosions. Advances in the understanding of the neuropathophysiology of TBI suggest that these forces initiate an elaborate and complex array of cellular and subcellular events related to alterations in Ca⁺⁺ homeostasis and signaling. Furthermore, there is a fairly predictable profile of brain regions that are impacted by neurotrauma and the related events. This profile of brain damage accurately predicts the acute and chronic sequelae that TBI survivors suffer from, although there is enough variation to suggest that individual differences such as genetic polymorphisms and factors governing resiliency play a role in modulating outcome. This paper reviews our current understanding of the neuropathophysiology of TBI and how this relates to the common clinical presentation of neurobehavioral difficulties seen after an injury.

Biography:

Dr.M.Ramachandran,M.D.,D.M.,FNB,ACCF Cardiologist Palaninta vilai Keezhkulam-629193, INDIA.

Abstract:

Abstract: Brain abscess is an intraparenchymal infection of brain parenchyma and begins with a localized area of inflammatory change referred to as ‘cerebritis’, progress to immature capsule stage and then to abscess, containing pus encapsulated by a vascularized membrane. The capsule serves to prevent the infective process from becoming generalized and it also create within it an inflammatory “soup” that may impede resolution of the infection. The incidence of brain abscess is about 8% of intracranial masses in developing countries and in cyanotic heart disease, its incidence varies from 5 to 18.7%. In patients with right-to-left shunts, absence of pulmonary phagocytic clearance of pathogens can occur and the ischemic injury from hypoxaemia and polycyathaemia, produce low perfusion areas in the brain which may act as a nidus for infection and anaerobic streptococci are the most common agents isolated in cyanotic heart disease with brain abscess. All abscesses > 1 cm produce positive scans and CT brain appears to be adequate in most cases of brain abscess. Third generation cephalosporins (cefotaxime or ceftriaxone) combined with metronidazole for 2 weeks followed by 4 weeks of oral therapy is the medical treatment of choice for cyanotic brain abscess. Surgical techniques such as drainage via burr-hole, complete excision after craniotomy, migration technique and neuroendoscopic technique with freehand stereotaxy  have also been practiced in the treatment of brain abscess.

Biography:

Professor Madana Mohiuddin Bonab, pioneer of stem cell Therapy application in the treatment of MS, is one of the authors of this study. She is the best technologist awarded in 13^th, Anniversary meeting of Pardis Technology Park in 2015 and Co-author of “Multiple Sclerosis A Mechanistic view“ , “Neuroinflammatiom“  and “The neurobiology of multiple sclerosis".

Abstract:

CADASIL, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy, is an inherited small vessels disease that characterized by central nervous system dysfunctions caused by mutations in the Notch-3 gene. Clinical manifestations accrue due to brain’s vasculopathy, neurodegeneration, and immune system reaction. We describe here an effective method for treatment of CADASIL by using mesenchymal stem cell therapy. A CADASIL case, 36 years old man, neuroimaging and genetic analysis for Notch-3 confirmed the diagnosis, is reported. In the present case, two stem cell injections have been performed at intervals of three weeks. The patient had no significant complications in the post-transplant period. No immediate or delayed side effects following MSC infusion were observed. He developed neither malignancy nor unwanted cells or any infectious complications 18 months after the transplantation, we performed a Cerebral MRI showed stable cerebral lesions and his gate and balance improved. Anti-HLA Antibody measurement confirmed that the patient's immune system was not stimulated by injected cells.With regard to his neurological symptoms, Scale for the assessment and rating of ataxia (SARA), The Multiple Sclerosis Functional Composite measure (MSFC), Quality of Life Assessment (QOL),and Cognitive Functioning Status (ACE-R), the patient did not has further deterioration  of his previous clinical status in the follow up period of 18 months.Further studies need to be performed to show the generalizability of the results.

Biography:

Dr. Buzz is a nationally recognized speaker specializing in children and adolescents with behavioral and emotional disabilities. His high energy, no-nonsense presentations deliver strategies and insights educators can use the next day.

Abstract:

Dr. Buzz will define and address the function of the cortical and subcortical structures of the brain. Within the Subcortical region of the brain, he will explain the difference between the Sympathetic and Parasympathetic Nervous System. Within the Sympathetic Nervous system, Dr. Buzz will explain in detail how humans suffer from “Inescapable Stress to the Brain” which results in unstable behavioral reactions activated by unstable limbic systems caused by Psychological and Emotional Trauma. Examples of Trauma patient’s conditions will be described, behavioral manifestations of Trauma victims will be displayed, and effective treatment solutions will be taught to the audience as well.

Biography:

Abstract:

Stroke is one of the cerebrovascular diseases. Stroke is different in children and newborns than it is in adults. Causes of stroke are also different in children than they are in adults. Stroke is more common in boys than girls, even after controlling for differences in frequency of causes such as trauma. It is a heterogeneous disease and one of the leading causes of death in children. The incidence of pediatric stroke ranges from 1.2 to 13 cases per 100,000 children under 18 years of age. There are several types of stroke including: ischemic, hemorrhagic, or both. Ischemic stroke in children accounts for about half of all stroke cases. Many different risk factors have been reported for childhood stroke, which cardiac disease, hemorrhagic abnormality, vasculopathies, viral infections, and veno-arterial malformation are of more importance. These factors are different from adults that including hypertension, diabetes, and atherosclerosis. The aim of this study was to determine the most common risk factors for stroke in children.

Biography:

Abstract:

Stroke is one of the cerebrovascular diseases. Stroke is different in children and newborns than it is in adults. Causes of stroke are also different in children than they are in adults. Stroke is more common in boys than girls, even after controlling for differences in frequency of causes such as trauma. It is a heterogeneous disease and one of the leading causes of death in children. The incidence of pediatric stroke ranges from 1.2 to 13 cases per 100,000 children under 18 years of age. There are several types of stroke including: ischemic, hemorrhagic, or both. Ischemic stroke in children accounts for about half of all stroke cases. Many different risk factors have been reported for childhood stroke, which cardiac disease, hemorrhagic abnormality, vasculopathies, viral infections, and veno-arterial malformation are of more importance. These factors are different from adults that including hypertension, diabetes, and atherosclerosis. The aim of this study was to determine the most common risk factors for stroke in children.

Biography:

Abstract:

Amyotrophic lateral sclerosis (ALS) is described as a progressive and lethal disease characterized by the degeneration of motor neurons localized in brain, brain stem, and spinal cord. Several mechanisms including mitochondrial dysfunction, apoptosis, inflammation, protein degradation and oxidative stress are associated with the initiation of the neurodegenerative process of ALS. The free radical scavenger Edavarone was reported to reduce speed of disease progression in early phase ALS, however there are no published data indicating biochemical or neurophysiological markers to quantify the impact of Edavarone. Blood and serum samples were collected from three cousins with heterozygous Leu144Phe mutation on fifth exon of SOD-1 gene were administered with Edavarone for one year as after-before treatment periods. Afterwards oxidative stress metabolism was investigated via glucose-6 phosphate dehydrogenase (G6PD), 6-phosphoglucanate dehydrogenase (6PGD), glutathione reductase (GR), glutathione-s transferase (GST), glutathione peroxidase (GPx), TAS, TOS, total thiol and native thiol in the erythrocytes. Moreover, 28 trace element and mineral were investigated via ICP-MS in the erythrocytes and serum samples. Needle EMG, sensory nerve action potentials (SNAPs), demographics and neurological examination were used to evaluate neurological markers. First time in the literature, our data showed that Edavarone ameliorates biochemical and neurological biomarkers at the early phase.